Inhibitors of ANF metabolism. Potential therapeutic agents in cardiovascular disease.

Inhibitors of ANF metabolism. Potential therapeutic agents in cardiovascular disease.

A trial natriuretic factor (ANF), a 28-amino acid peptide hormone synthesized and secreted from atrial myocytes, has been suggested to play an important role in the regulation of extracellular fluid volume and arterial pressure. Physiological and pharmacological doses of this peptide have been shown to produce natriuresis and diuresis, vasorelaxation, and inhibition or antagonism or both of imp...

Potential Therapeutic Agents in Cardiovascular Disease

A trial natriuretic factor (ANF), a 28-amino acid peptide hormone synthesized and secreted from atrial myocytes, has been suggested to play an important role in the regulation of extracellular fluid volume and arterial pressure. Physiological and pharmacological doses of this peptide have been shown to produce natriuresis and diuresis, vasorelaxation, and inhibition or antagonism or both of imp...

Inhibitors of the Ubiquitin-Proteasome System as Potential Therapeutic Agents for Cardiovascular Diseases

Molecular weight heterogeneity of plasma-ANF in cardiovascular disease.

Structural differences of circulating ANF may partly explain why the physiological response of the heart in controlling volume/pressure loading in cardiovascular disease states remains insufficient in spite of elevated ANF plasma levels. Structural analysis of plasma ANF immunoreactivity was performed by means of gel permeation of plasma extracts subsequent to radioimmunoassay. ANF plasma level...

Cyclic AMP efflux inhibitors as potential therapeutic agents for leukemia

Apoptotic evasion is a hallmark of cancer. We propose that some cancers may evade cell death by regulating 3'-5'-cyclic adenosine monophosphate (cAMP), which is associated with pro-apoptotic signaling. We hypothesize that leukemic cells possess mechanisms that efflux cAMP from the cytoplasm, thus protecting them from apoptosis. Accordingly, cAMP efflux inhibition should result in: cAMP accumula...